P042 Distinct gene expression profile associated to inflammation and neoplastic progression in longstanding ulcerative colitis

Abstract Background One of the main drivers colitis associated colorectal cancer (CA-CRC) is suspected to be long-standing mucosal inflammation, but far from all patients develop cancer. We analyzed gene expression profiles in ulcerative (UC) who have progressed neoplasia (progressors) compared those not (non-progressors) order identify underlying mechanisms for neoplastic progression UC patients. Methods performed transcriptome profiling on 143 samples non-neoplastic colon segments 14 progressors and 30 non-progressors prospective CA-CRC cohorts Lovisenberg Diakonale- Akershus University Hospitals Norway. Differentially expressed genes were determined using SurePrint G3 human 60K microarray (Agilent Tech Inc.). Results 609 differentially between non-progressor- progressor inflamed tissue, 24 non-inflamed 404 non-progressor non-inflamed- -inflamed tissue 26 tissue. In mucosa, related metabolic processes such as xenobiotic- well carbohydrate lipid metabolism significantly higher non-progressors. Genes innate adaptive immune responses at lower levels. These traits influenced by type inflammation apparent both, chronic- chronic active inflammation. However, mucosa also characterised dysregulation chromatin organization. Treatment with immunomodulators biologics equally distributed groups. Restriction analysis without treatment these drugs did influence results. profile remarkably similar. fact, within positively negatively enriched ontologies, only S100P was deregulated a progressors. Conclusion Upregulated detoxification dysregulated response organization may colitis. Our findings warrant further evaluation.